A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS

Document Type : Original Article

Authors

1 forensic medicine and clinical toxicology department , faculty of medicine,Zagazige unversity

2 Department of Forensic Medicine and Clinical Toxicology; Faculty of Medicine; Zagazig University

Abstract

Background: Parabens induced toxic effects on different body organs via induction of oxidative stress. Naringenin is considered as potent free radicals scavenger. Aim of the work: to investigate antioxidant effect of naringenin on the lungs toxicity induced from parabens in adult male albino rats. Materials and Methods: The research study have been conducted on 30  adult male albino rats divided into five groups each of 6 rats: Group I a (negative control group): No intervention was done. Group I b (positive control group): Rats received 0.2 ml pea nut oil orally for 8weeks. Group II (naringenin group): Rats received naringenin (50 mg/kg body weight) dissolved in water orally. Group III (parabens treated group): Rats were administrated 1/10 of the lethal dose of the butyl parabens which equal to (4.6 mg/rat/day) dissolved in pea nut oil orally for 8 weeks. Group IV (parabens and naringenin treated group): Rats were administered parabens and naringenin orally once daily for 8 weeks. Twenty- four hours after the end of experiment, the rats were subjected to sampling of blood for estimating oxidative markers and interlukin-6. Lung tissues were examined by light microscope. Results: This study revealed impairment in oxidative markers and interlukin-6 with histopathological changes in lung tissues in parabens treated group and these effects were ameliorated by intake of naringenin. Conclusion: Parabens oxidative stress damage can be ameliorated by naringenin supplementation.

Keywords

Files

Share

How to cite

Statistics