Shalaby, N., mahmoud, A. (2023). A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS. Zagazig Journal of Forensic Medicine and Toxicology, 21(2), 84-97. doi: 10.21608/zjfm.2023.211876.1149
Nashwa Mohamad Mohamad Shalaby; Abeer Ramzy Hussieny mahmoud. "A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS". Zagazig Journal of Forensic Medicine and Toxicology, 21, 2, 2023, 84-97. doi: 10.21608/zjfm.2023.211876.1149
Shalaby, N., mahmoud, A. (2023). 'A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS', Zagazig Journal of Forensic Medicine and Toxicology, 21(2), pp. 84-97. doi: 10.21608/zjfm.2023.211876.1149
Shalaby, N., mahmoud, A. A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS. Zagazig Journal of Forensic Medicine and Toxicology, 2023; 21(2): 84-97. doi: 10.21608/zjfm.2023.211876.1149
A STUDY OF POTENTIAL PROTECTIVE EFFECT OF NARINGENIN ON LUNG TOXICITIES INDUCED BY PARABENS IN ADULT MALE ALBINO RATS
1forensic medicine and clinical toxicology department , faculty of medicine,Zagazige unversity
2Department of Forensic Medicine and Clinical Toxicology; Faculty of Medicine; Zagazig University
Abstract
Background: Parabens induced toxic effects on different body organs via induction of oxidative stress. Naringenin is considered as potent free radicals scavenger. Aim of the work: to investigate antioxidant effect of naringenin on the lungs toxicity induced from parabens in adult male albino rats. Materials and Methods: The research study have been conducted on 30 adult male albino rats divided into five groups each of 6 rats: Group I a (negative control group): No intervention was done. Group I b (positive control group): Rats received 0.2 ml pea nut oil orally for 8weeks. Group II (naringenin group): Rats received naringenin (50 mg/kg body weight) dissolved in water orally. Group III (parabens treated group): Rats were administrated 1/10 of the lethal dose of the butyl parabens which equal to (4.6 mg/rat/day) dissolved in pea nut oil orally for 8 weeks. Group IV (parabens and naringenin treated group): Rats were administered parabens and naringenin orally once daily for 8 weeks. Twenty- four hours after the end of experiment, the rats were subjected to sampling of blood for estimating oxidative markers and interlukin-6. Lung tissues were examined by light microscope. Results: This study revealed impairment in oxidative markers and interlukin-6 with histopathological changes in lung tissues in parabens treated group and these effects were ameliorated by intake of naringenin. Conclusion: Parabens oxidative stress damage can be ameliorated by naringenin supplementation.
View on SCiNiTO
Top