Fekry, E., Awny, M., Refaat, G., Arafat, H. (2023). Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism.. Zagazig Journal of Forensic Medicine and Toxicology, 21(1), 172-189. doi: 10.21608/zjfm.2023.188310.1139
Ereny Fekry; Mona Awny; George Refaat; Horeya Arafat. "Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism.". Zagazig Journal of Forensic Medicine and Toxicology, 21, 1, 2023, 172-189. doi: 10.21608/zjfm.2023.188310.1139
Fekry, E., Awny, M., Refaat, G., Arafat, H. (2023). 'Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism.', Zagazig Journal of Forensic Medicine and Toxicology, 21(1), pp. 172-189. doi: 10.21608/zjfm.2023.188310.1139
Fekry, E., Awny, M., Refaat, G., Arafat, H. Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism.. Zagazig Journal of Forensic Medicine and Toxicology, 2023; 21(1): 172-189. doi: 10.21608/zjfm.2023.188310.1139
Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism.
1Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
2Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Internal Medicine and Cardiology Departments, Suez Canal Authority, Ismailia, Egypt
Abstract
Introduction: Carbimazole is an antithyroid medication that is used for the treatment of hyperthyroidism. Carbimazole decreases serum thyroxine, thyroid-stimulating hormone, and thyrotropin-binding inhibitory immunoglobulins. However, carbimazole therapy can induce hypothyroidism and toxic effects on the thyroid gland tissue itself. Saussurea lappa root “Costus” is a traditional treatment that has anti-inflammatory, antioxidant, and immunomodulatory properties. Materials and methods: Twenty-four adult male albino rats were equally randomized into four groups and received all treatments orally by intragastric tube: group I served as control. Group II received Costus roots aqueous extract (50mg/kg body weight /2 days). Group III received carbimazole (2mg/100 gm body weight/day). Group IV received carbimazole concomitant with Costus roots aqueous extract. After 4 weeks, the animals were decapitated. Hematoxylin and eosin stain, periodic acid-Schiff reaction, and anti-calcitonin immunostaining were all performed on the prepared sections. Results: The Carbimazole group showed follicles lined by squamous epithelium, vacuolated colloid, and fused follicles. Carbimazole caused markedly decreased PAS-positive reaction due to colloid vacuolations and increased cytoplasmic immunoreactivity of C cells. In group IV, Costus could restore almost all the histopathological changes and improved C cells and decreased their cytoplasmic immunoreactivity. Conclusion: Saussurea lappa root “Costus” has a protective effect against carbimazole-induced thyroid damage.
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