THE ROLE OF LIPID EMULSION IN TREATMENT OF ACUTE TRAMADOL TOXICITY IN ADULT MALE ALBINO RATS

El Zahed, Eman Salah; Khalefa, Abeer Albiomy; Shalaby, Nashwa Mohamad; Ahmed, Fatma Ibrahim

doi:10.21608/zjfm.2018.2586.1009

THE ROLE OF LIPID EMULSION IN TREATMENT OF ACUTE TRAMADOL TOXICITY IN ADULT MALE ALBINO RATS

Document Type : Original Article

Authors

¹ forensic medicine and clinical toxicology department

² physiology department,faculty of medicine,zagazige unversity

³ forensic medicine and clinical toxicology department , faculty of medicine,Zagazige unversity

⁴ forensic medicine and clinical toxicology department,faculty of medicine,zagazige university

10.21608/zjfm.2018.2586.1009

Abstract

Tramadol is a synthetic centrally acting analgesic for treatment of moderate to severe acute or chronic pain. In tramadol overdose, there are seizures and hypotension. Intravenous lipid emulsion (ILE) is a recognized, effective treatment for local anesthetic-induced cardiovascular collapse, and treating overdoses of parasiticides, and herbicides. The aim of this work was to evaluate the role of ILE in acute tramadol toxicity as regarding hemodynamic instability and seizures in adult male albino rats.
Eighty adult male albino rats were used. Rats were divided into five groups: Group I (-ve control group). Group II (+ve control group), divided into; normal saline, ILE10, ILE19 subgroups. Group III (tramadol treated group). Group IV: (tramadol and normal saline treated group). Group V: divided into tramadol+ILE10 and tramadol+ILE19 subgroups. Measurement of blood pressure, monitoring of heart rate and observation for occurrence of seizures were recorded.
Different doses of ILE significantly normalized DBP and HR. After infusion of ILE 20%, MAP was significantly stabilized. The ILE10 group had higher MAP at 6 hours, whereas such effect was seen only in ILE19 after 24 hours. There was a decrease in seizures occurrence in ILE treated groups. Serum CPK levels were significantly raised after tramadol toxicity and reduced to normal ranges when ILE was administered in both doses.
Tramadol causes Hemodynamic instability and appearance of seizures after once administration (150 mg/kg). ILE could significantly normalize Hemodynamic and seizures of tramadol toxicity.

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