Mahmoud, E., Hussien, R., George, S., Refaiy, A., Radwan, R. (2022). The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats. Zagazig Journal of Forensic Medicine and Toxicology, 20(2), 319-338. doi: 10.21608/zjfm.2021.71789.1075
Emadeldin Mahmoud; Randa Hussien; Safaa George; Abeer Refaiy; Rania Ahmed Radwan. "The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats". Zagazig Journal of Forensic Medicine and Toxicology, 20, 2, 2022, 319-338. doi: 10.21608/zjfm.2021.71789.1075
Mahmoud, E., Hussien, R., George, S., Refaiy, A., Radwan, R. (2022). 'The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats', Zagazig Journal of Forensic Medicine and Toxicology, 20(2), pp. 319-338. doi: 10.21608/zjfm.2021.71789.1075
Mahmoud, E., Hussien, R., George, S., Refaiy, A., Radwan, R. The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats. Zagazig Journal of Forensic Medicine and Toxicology, 2022; 20(2): 319-338. doi: 10.21608/zjfm.2021.71789.1075
The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats
1Aswan university faculty of medicine. forensic medicine and clinical toxicology department
2Forensic medicine and Clinical Toxicology department, Faculty of medicine, Assiut University. Assiut city Egypt
3forensic medicine and clinical toxicology, faculty of medicine, assiut university. Assiut city.
4Pathology department, Faculty of medicine, Assiut University Assiut city
5Forensic Medicine and Clinical Toxicology, Faculty of medicine, Sohag University, Sohag, Egypy
Abstract
Doxorubicin (DOX) is an anthracycline antibiotic and a quinone-containing chemotherapeutic drug used for various types of solid and hematological cancers. However, it causes many toxic side effects, including cardiac, renal, hematological, and testicular. The current study investigated the ameliorative effect of n-acetylcysteine against DOX-induced cardiotoxicity in albino rats. Sixty rats were divided into six groups. Group (A): rats received food pellets and tap water ad libitum. Group (B): rats received NAC (400 mg/kg/p.o.) Every other day for 28 days. Group (C): rats received DOX (5 mg/kg, i.p.) for four weeks on days 1, 7, 14 and 21. Group (D): rats received NAC (400 mg/kg/p.o.) every other day one week earlier and then along with DOX (5 mg/kg/ i.p.) for the next four weeks on days 1, 7, 14 and 21). Group (E): rats received NAC (400 mg/kg/ p.o.) every other day started at the first day of the experiment till the end of the experiment and DOX (5 mg/kg/ i.p.) for four weeks on day 1, 7, 14 and 21. Group (F): rats received NAC (800 mg/kg, p.o.) every other day started at the first day of the experiment till the end of the experiment and DOX (5 mg/kg, i.p.) for four weeks on day 1, 7, 14 and 21. Results showed a significant increase in levels of LDH, CK-MB, CTn-I, and (MDA). Whilst, levels of (GSH) and (GSH-Px) were significantly decreased. Moreover, there were histopathological abnormalities in the cardiac tissue of DOX-treated rats. The study demonstrated that NAC has a cardioprotective effect on the damage induced by DOX, through inhibition of inflammation and oxidative stress. This effect was more pronounced in groups (D, E&F), as it produced a significant increase in GSH and GSH-Px levels, a significant decrease in MDA, LDH, CK-MB, and CTn-I.
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